Marijuana Could be the Answer to Curing Alzheimer's Disease, Study Shows
Sean Williams - The Motley Fool
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September 26, 2016

Samuel Cohen: Alzheimer’s Is Not Normal Aging — and We Can Cure It (TED Talks)

The statistics associated with Alzheimer's disease are downright depressing.

The disease, which typically affects the elderly and is characterized by a progressive decline in cognitive function, currently afflicts 5.4 million Americans, and the Alzheimer's Association expects the direct and indirect costs of treatment to reach $236 billion in 2016. Some one in nine people over the age of 65 has Alzheimer's disease, and within the U.S., it's the sixth-leading cause of death.

These statistics are even scarier when you consider how much researchers still have to learn about this disease. Though there are medications designed to slow the progression of the various stages of the disease, a cure for Alzheimer's disease remains elusive for the time being.

A number of big-name drug developers have taken aim at Alzheimer's, only to have their studies end in disappointment. Drug giants Johnson & Johnson and Pfizer teamed up to develop bapineuzumab, while Eli Lilly developed solanezumab. Both drugs missed their primary endpoints in phase 3 studies. It's difficult to get medicine through the blood-brain barrier, and the clinical success rate of Alzheimer's drugs is particularly low.

Biogen is hoping to change that with experimental therapy aducanumab, which, in early-stage studies, produced reduced cognitive decline and substantial beta-amyloid clearance. (Beta-amyloid is a protein found around the brain that, when clumped together, can form plagues that block neurons and lead to a progressive decline in cognitive function.) Unfortunately, early-stage success stories often miss the mark in later-stage studies, so the jury is still out on aducanumab.

However, researchers at the Salk Institute for Biological Studies believe the cure to Alzheimer's disease might come from a readily available substance: marijuana.

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